If you’re looking for one of the most advanced course formats (which lets you deconstruct your Moodle course to it’s fundamental parts and then rebuild it from scratch in any format you want) then Flexpage is something you should look at. Flexpage is a premium supported addon and feature for Moodlerooms clients but is available to the community now and has been updated and released for Moodle 2.3 in the Moodle.org Plugin and Addons repository.
From the format description,
Flexpage is a course format that provides a teacher with complete control over how educational materials and assessments are presented to a student. Flexpage allows a teacher to create a flexible set of pages and sub pages where blocks and activities can be placed in any location on the page instead of being restricted to a right, left or center column. Flexpage courses provide teachers with the ability to determine how many columns of data are contained within a course (up to three-columns). This allows teachers to have complete control over how they want to present course materials and assessments to students.
Note that there are a few pieces of the plugin that need to be installed for it to work properly (read up about installation and more at http://docs.moodle.org/22/en/Flexpage):
When all are installed you can do some pretty cool things (though the learning curve is nothing to be laughed at) with a course layout and design. Here are a few screenshots of my experience with Flexpage in the past.